Pyramidal neurons

Pyramidal Neurons

The effect of the fluorescent Ca2+ indicator dye Fura-2 on Ca2+ dynamics was studied in proximal apical dendrites of neocortical layer V and hippocampal CAl pyramidal neurons in rat brain slices using somatic whole-cell recording and a charge-coupled device camera. A single action potential evoked a transient increase of intradendritic calcium concentration ([Ca2+]i) that was reduced in size an...

Pyramidal neurons

Figure 1. Dendritic morphologies of typical pyramidal neurons in different brain regions. (A) Layer 5 pyramidal neuron in the rat somatosensory cortex (courtesy of Maarten Kole). (B) Pyramidal neuron in area CA3 of the rat hippocampus (reproduced with permission from Gonzales et al. (2001).) (C) Layer 2 pyramidal neuron in the primary olfactory cortex of the mouse (unpublished work of Norimitsu...

Effects of resveratrol on intrinsic neuronal properties of CA1 pyramidal neurons in rat hippocampal slices

Introduction: Resveratrol (3,5,4-trihydroxystilbene) a non-flavonoid polyphenol found in some plants like grapes, peanuts and pomegranates, possesses a wide range of biological effects. Evidence indicates that resveratrol has beneficial effects on nervous system to induce neuroprotection. However, the cellular mechanisms of the effects are not fully determined. In the present study, the cellula...

Cholinergic inhibition of neocortical pyramidal neurons.

Acetylcholine (ACh) is a central neurotransmitter critical for normal cognitive function. Here we show that transient muscarinic acetylcholine receptor activation directly inhibits neocortical layer 5 pyramidal neurons. Using whole-cell and cell-attached recordings from neurons in slices of rat somatosensory cortex, we demonstrate that transient activation of M1-type muscarinic receptors induce...

From pyramidal neurons to peripheral nociceptors